Single Cell Inoculations with Treponema Pallidum
نویسندگان
چکیده
The injection of one or several Treponema pallidum into the testicles of rabbits does not induce syphilitic infection. A negative tissue transfer experiment does not preclude the presence of Treponema pallidum in the inoculum nor does it indicate the absence of syphilis in the source animal.
منابع مشابه
Characterization of the attachment of Treponema pallidum (Nichols strain) to cultured mammalian cells and the potential relationship of attachment to pathogenicity.
The interaction of Treponema pallidum (Nichols strain) with 19 different cultured mammalian cell types was examined. These types included cells derived from testis, kidney, spleen, lung, epidermis, cervix, urethra, and nerve tissue of human, rabbit, or rat origins. They represented normal and malignant cells, epithelial and fibroblastic morphology, cell lines, and cell strains, Large numbers of...
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1. By inoculating the scarified surface of both sides of the scrotum of rabbits with suspensions of Treponema pallidum, 100 per cent of infections were obtained on one side or the other. Infection through the unbroken skin could not be produced. 2. By gland transfers from animals with positive local inoculations, 87.5 per cent of takes were produced. 3. These two methods were used to test the p...
متن کاملMelanoma (sarcoma) of the Eye in a Syphilitic Rabbit
A melanotic tumor developed in a defective eye of a syphilitic rabbit following repeated genital inoculations with Treponema pallidum. The appearance of the tumor coincided with the development of a syphilitic lesion in the same eye, suggesting a relation between the occurrence of the two lesions.
متن کاملMolecular cloning and characterization of the 15-kilodalton major immunogen of Treponema pallidum.
Pathogen-specific membrane immunogens of Treponema pallidum subsp. pallidum (T. pallidum) have been identified previously by phase partitioning with the nonionic detergent Triton X-114. One of these antigens, a 15-kilodalton (kDa) polypeptide, is expressed in relatively small quantities in T. pallidum but is highly immunogenic in both human and experimental syphilis. The native T. pallidum anti...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 59 شماره
صفحات -
تاریخ انتشار 2003